Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTTargeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of ResistanceGergely Szakács*†, Matthew D. Hall‡, Michael M. Gottesman‡, Ahcène Boumendjel§, Remy Kachadourian∥⊥, Brian J. Day∥⊥, Hélène Baubichon-Cortay#, and Attilio Di Pietro*#View Author Information† Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, Budapest 1117, Hungary‡ Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States§ Département de Pharmacochimie Moléculaire, Université de Grenoble/CNRS, UMR 5063 BP53, 38041 Grenoble Cedex 9, France∥ Department of Medicine, National Jewish Health, Denver, Colorado 80206, United States⊥ Departments of Medicine and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado 80045, United States# Equipe Labellisée Ligue 2014, BMSSI UMR 5086 CNRS/Université Lyon 1, IBCP, 7 passage du Vercors, 69367 Lyon Cedex 07, France*E-mail: [email protected]*E-mail: [email protected]. Phone: +33-4-7272-2629. Fax: +33-4-7272-2604.Cite this: Chem. Rev. 2014, 114, 11, 5753–5774Publication Date (Web):April 23, 2014Publication History Received31 October 2013Published online23 April 2014Published inissue 11 June 2014https://doi.org/10.1021/cr4006236Copyright © 2014 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views5054Altmetric-Citations141LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (7 MB) Get e-AlertsSUBJECTS:Cells,Drug resistance,Inhibitors,Peptides and proteins,Toxicity Get e-Alerts