Epigenetic control of gene expression occurs at two distinct levels: DNA methylation and histone modification. Over the past 10 years, the discovery of epigenetic targets has accelerated to the point where more than 400 domains have been identified that are involved in either DNA methylation, the modification of histones (and some nonhistones), or translation of these modifications into changes in gene expression. Clinical Pharmacology & Therapeutics (2012); 92 6, 689–693. doi:10.1038/clpt.2012.154
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Müller et al. (2012) studied this question.
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