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March 23, 2017Science186 citationsOpen Access

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

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JLJun LiAnhui Agricultural UniversityMBMichael S. BonkowskiHarvard UniversitySMS. MoniotMerck (Germany)

Key Points

  • The aim is to explore how a conserved NAD+ binding pocket affects protein-protein interactions, particularly during aging.
  • Identified a specific NAD+ binding pocket regulating interactions among proteins.
  • Evaluated the effects of modulating these interactions on aging-related processes.
  • Enhanced protein-protein interactions correlated with reduced aging markers, with a significant effect size (p<0.05).
  • Modulation was linked to lower incidence rates of cancer and improved resilience to radiation exposure.

Abstract

directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging.

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Cite This Study

Li et al. (2017) studied this question.

synapsesocial.com/papers/6a0cb3fb93c2b42b5c887cdehttps://doi.org/10.1126/science.aad8242
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