RIG-I-like receptors (RLRs) function as accurate sensors of virus invasion by discriminating between the RNA content of healthy versus virus-infected cells.
This review summarizes the mechanisms by which RIG-I-like receptors (RLRs) detect viral RNA to initiate cell-intrinsic antiviral defenses.
Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I-like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.
Rehwinkel et al. (Thu,) conducted a review in Virus infection. RIG-I-like receptors (RLRs) function as accurate sensors of virus invasion by discriminating between the RNA content of healthy versus virus-infected cells.
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