What question did this study set out to answer?

Determine the role of epithelial exosomes and their transported molecular cargo in mediating epithelial-mesenchymal communication during organ development.

July 20, 2017ACS Nano

Exosomes Mediate Epithelium–Mesenchyme Crosstalk in Organ Development

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Authors

NJNan JiangShenyang Pharmaceutical University LXLusai XiangStomatology Hospital LHLing HeCentral South University

Discussion

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Overview

Experimental study reveals that epithelial exosomal miR135a enhances mesenchymal dentin matrix production in mice, highlighting therapeutic avenues for tissue regeneration.

Key Points

Determine the role of epithelial exosomes and their transported molecular cargo in mediating epithelial-mesenchymal communication during organ development.
Profiled microRNAs and peptides contained within exosomes isolated from mutant mice.
Screened epithelial exosomal microRNAs against known regulators of the Wnt signaling pathway.
Assessed the regulatory effects of exosomal miR135a and its inhibitor, Antago-miR135a, on mesenchymal cells.
Epithelium exosome-derived miR135a activated the Wnt/β-catenin signaling pathway.
MiR135a increased mesenchymal production of dentin matrix proteins, an outcome partially reversed by Antago-miR135a attenuation.

Cite This Study

Jiang et al. (2017) studied this question.

synapsesocial.com/papers/6a0cc8df3239dcc1e4625969 https://doi.org/10.1021/acsnano.7b01087

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July 20, 2017ACS Nano

Exosomes Mediate Epithelium–Mesenchyme Crosstalk in Organ Development

View Full Paper

Ask AI

Bookmark

Authors

NJNan JiangShenyang Pharmaceutical University LXLusai XiangStomatology Hospital LHLing HeCentral South University

Discussion

Member takes

Overview

Experimental study reveals that epithelial exosomal miR135a enhances mesenchymal dentin matrix production in mice, highlighting therapeutic avenues for tissue regeneration.

Key Points

Determine the role of epithelial exosomes and their transported molecular cargo in mediating epithelial-mesenchymal communication during organ development.
Profiled microRNAs and peptides contained within exosomes isolated from mutant mice.
Screened epithelial exosomal microRNAs against known regulators of the Wnt signaling pathway.
Assessed the regulatory effects of exosomal miR135a and its inhibitor, Antago-miR135a, on mesenchymal cells.
Epithelium exosome-derived miR135a activated the Wnt/β-catenin signaling pathway.
MiR135a increased mesenchymal production of dentin matrix proteins, an outcome partially reversed by Antago-miR135a attenuation.

Cite This Study

Jiang et al. (2017) studied this question.

synapsesocial.com/papers/6a0cc8df3239dcc1e4625969 https://doi.org/10.1021/acsnano.7b01087

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