December 17, 2025Netherlands Heart Journal1 citationsOpen Access

Incidence and trends of patient MACE outcomes after Transcatheter Aortic Valve Implantation (TAVI): analysis by age and sex

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Aortic stenosis (n=19746). Intervention: Transcatheter Aortic Valve Implantation (TAVI) vs. Earlier time period (2013-2014). Primary outcome: 30-day mortality (p=<0.001).

TYTsvetan R. YordanovGGD Amsterdam HAHatem Al‐FarraGGD Amsterdam ARAnita C.J. RavelliAmsterdam UMC Location University of Amsterdam

Key Result

Transcatheter aortic valve implantation outcomes improved significantly between 2013 and 2022, with 30-day mortality decreasing from 6.7% to 2.7% and one-year mortality decreasing from 15.8% to 8.8%.

Study Design

Type

Observational (n=19,746)

Multicenter

Yes

Structured PICO

Population

19,746 patients undergoing transcatheter aortic valve implantation (TAVI) from the Netherlands Heart Registration (NHR) between 2013 and 2022, mean age 80 years.

Intervention

Transcatheter Aortic Valve Implantation (TAVI)

Outcome

Mortality at 30 days, mortality at one year, permanent pacemaker implantation at 30 days (PPI), major vascular complication at 30 days (MVC), and stroke at three dayshard clinical

Between 2013 and 2022, TAVI procedural volumes increased significantly while the incidence of mortality and major complications decreased, though sex-specific differences in outcomes persist.

Main Result

Absolute Event Rate: 2.7% vs 6.7%

p-value: p=<0.001

Limitations

Retrospective registry analysis
Combined MACE incidence likely underestimates the true one-year rate due to varying follow-up times for different components
Heterogeneity in endpoint definitions compared to previous reports
Dataset does not capture details on prosthesis type or generation

Abstract

Abstract Background Patients undergoing a transcatheter aortic valve implantation (TAVI) are at risk for Major Adverse Cardiac Events (MACE). We describe temporal trends of TAVI-related MACEs, stratified by age and sex. Methods We performed a retrospective analysis of TAVI patients from the Netherlands Heart Registration (NHR) between 2013 and 2022. The outcomes were: mortality at 30 days, mortality at one year, permanent pacemaker implantation at 30 days (PPI), major vascular complication at 30 days (MVC), and stroke at three days. We calculated incidence and trends in TAVI patients and their outcomes. Results The cohort consisted of 19,746 TAVI patients, with a mean age of 80 years. The annual number of TAVI procedures increased over the years from 786 to 2876 ( p < 0.001). Initially, more women received TAVI, but the trend shifted over time to more men ( p < 0.001). Outcomes incidence was: 30-day mortality (3.3%), one-year mortality (10.6%), PPI (10.7%), MVC (2.9%), and stroke (2.0%). Incidence of both mortality outcomes decreased over time (6.7% to 2.7%, and 15.8% to 8.8% for 30-day and one-year mortality, respectively), as did PPI (12.3% to 10.4%) and MVC (3.6% to 2.5%). Women had a higher incidence of MVC and stroke. Men had a higher incidence of one-year mortality and PPI, and their incidence increased more with age than it did in women. Conclusion The volume of TAVI procedures has increased significantly over time, while mortality, PPI, MVC, and MACE incidence have significantly decreased. Sex-specific differences in MACE outcome incidence were present.

问 AI

Bookmark

View Full Paper