Key result
Alpha-methyldopa therapy reversed cardiac hypertrophy and normalized biochemical parameters except hydroxyproline, which increased significantly as myocardial weight decreased in hypertensive rats.
Why the study?
Does alpha-methyldopa therapy reverse biochemical alterations associated with cardiac hypertrophy in spontaneously hypertensive rats?
Does alpha-methyldopa therapy reverse biochemical alterations associated with cardiac hypertrophy in spontaneously hypertensive rats?
Alpha-methyldopa therapy reverses cardiac hypertrophy and normalizes most biochemical parameters in spontaneously hypertensive rats, except for hydroxyproline concentration which increases.
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Preclinical reversal of hypertrophy in rats leaves open clinical translation and human mechanistic studies.
Şen et al. (1976) studied Cardiac hypertrophy in spontaneously hypertensive rats. alpha-methyldopa vs. suitably matched controls was evaluated on Biochemical alterations of myocardium (DNA, RNA, hydroxyproline, 14C lysine incorporation). Alpha-methyldopa therapy reversed cardiac hypertrophy and normalized biochemical parameters except hydroxyproline, which increased significantly as myocardial weight decreased in hypertensive rats.
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