Key result
Alpha-methyldopa therapy reversed cardiac hypertrophy and normalized biochemical parameters except hydroxyproline, which increased significantly as myocardial weight decreased in hypertensive rats.
Why the study?
Does alpha-methyldopa therapy reverse biochemical alterations associated with cardiac hypertrophy in spontaneously hypertensive rats?
Does alpha-methyldopa therapy reverse biochemical alterations associated with cardiac hypertrophy in spontaneously hypertensive rats?
Alpha-methyldopa therapy reverses cardiac hypertrophy and normalizes most biochemical parameters in spontaneously hypertensive rats, except for hydroxyproline concentration which increases.
Preclinical reversal of hypertrophy in rats leaves open clinical translation and human mechanistic studies.
This study is the first report describing the sequence of biochemical alterations of myocardium during the progression of naturally occurring hypertrophy in spontaneously hypertensive rats (SHRs) and then with its reversal by alpha-methyldopa therapy. Changes in DNA, RNA, hydroxyproline, as well as incorporation of 14C lysine into cardiac myosin, were compared with the pattern found in suitably matched controls. A significant increase in RNA, hydroxyproline, and 14C incorporation was observed in SHRs. Antihypertensive treatment caused reversal of hypertrophy and normalization of all biochemical parameters except hydroxyproline, the concentration of which increased significantly as myocardial weight decreased. These compositional changes may help explain the conflicting result of the haemodynamic effects of cardiac hypertrophy.
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Şen et al. (1976) studied Cardiac hypertrophy in spontaneously hypertensive rats. alpha-methyldopa vs. suitably matched controls was evaluated on Biochemical alterations of myocardium (DNA, RNA, hydroxyproline, 14C lysine incorporation). Alpha-methyldopa therapy reversed cardiac hypertrophy and normalized biochemical parameters except hydroxyproline, which increased significantly as myocardial weight decreased in hypertensive rats.
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