Megakaryocytopoiesis was evaluated in Sl/Sld mice and their heterozygous and homozygous normal (+/+) littermates. Sl/Sld mice had a normal concentration of blood platelets which were of normal size. Numbers of megakaryocytes in bone marrow and spleen were reduced, but individual megakaryocytes were larger than normal.
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Ebbe et al. (1973) studied this question.
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