Key result
Elevated high-sensitivity troponin I linked to ~89% higher in-hospital mortality in neurosurgical and neurocritical patients.
Why the study?
To investigate whether high-sensitivity troponin I elevation is associated with in-hospital mortality and MACEs in neurosurgical and neurocritically ill patients.
Is high-sensitivity troponin I elevation associated with increased in-hospital mortality and major adverse cardiac events in neurosurgical and neurocritically ill patients?
Cohort (n=6,004)
Is high-sensitivity troponin I elevation associated with increased in-hospital mortality and major adverse cardiac events in neurosurgical and neurocritically ill patients?
High-sensitivity troponin I elevation is a significant predictor of in-hospital mortality and major adverse cardiac events in neurosurgical and neurocritically ill patients.
To investigate whether high-sensitivity troponin I (hs-TnI) elevation is associated with in-hospital mortality and major adverse cardiac events (MACEs) in neurosurgical and neurocritically ill patients. Among neurosurgical patients admitted to the intensive care unit (ICU) from January 2013 to December 2019, those whose serum hs-TnI levels were obtained within 7 days after ICU admission were included. Propensity score matching was used. Each patient with hs-TnI elevation was matched to a control patient. The primary endpoint was in-hospital mortality and the secondary outcome was MACEs. The hs-TnI elevation was shown in 848 (14.1%) of 6004 patients. After propensity score matching, 706 pairs of data were generated by 1:1 individual matching without replacement. In multivariable analysis of overall and propensity score-matched population, hs-TnI elevation was associated with in-hospital mortality (adjusted odds ratio (OR): 2.37, 95% confidence interval (CI): 1.68-3.33 and adjusted OR: 1.89, 95% CI: 1.28-2.81, respectively). In addition, hs-TnI elevation was associated with MACEs (adjusted OR: 2.73, 95% CI: 1.74-4.29 and adjusted OR: 2.64, 95% CI: 1.60-4.51, respectively). In this study, hs-TnI elevation was associated with in-hospital mortality and MACEs in neurosurgical and neurocritically ill patients.
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Lee et al. (2022) conducted a cohort in Neurosurgical and neurocritically ill patients (n=6,004). High-sensitivity troponin I (hs-TnI) elevation vs. No hs-TnI elevation was evaluated on In-hospital mortality (adjusted OR 1.89, 95% CI 1.28-2.81). High-sensitivity troponin I elevation was associated with increased in-hospital mortality in neurosurgical and neurocritically ill patients (adjusted OR 1.89; 95% CI 1.28-2.81).
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