Key result
Reaction of myosin with DMSDS formed regulatory light chain homodimers with 20-50% efficiency, indicating translationally equivalent sites on the two myosin heads can come within 18 A of each other.
Population
Mercenaria myosin and scallop pure hybrid myosin possessing Mercenaria regulatory light chains
Design
Preclinical
Authors
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Supports myosin head flexibility in vitro; leaves open relevance to cardiac contraction in vivo.
The study demonstrates that translationally equivalent sites on the two heads of myosin can come within 18 A of each other, consistent with considerable flexibility of the two myosin heads.
Chantler et al. (1988) studied None (In vitro biochemistry). 4-4'-dimaleimidylstilbene-2-2'-disulfonic acid (DMSDS) was evaluated on Formation of regulatory light chain homodimers. Reaction of myosin with DMSDS formed regulatory light chain homodimers with 20-50% efficiency, indicating translationally equivalent sites on the two myosin heads can come within 18 A of each other.
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