Key result
VRAP was identified as an adaptor protein that binds the intracellular domain of KDR, recruiting cytoplasmic signaling proteins important for VEGF-induced endothelial cell survival and proliferation.
Authors
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Remains preclinical; extends molecular map of VEGF-KDR signaling but leaves clinical relevance open.
Wu et al. (2000) studied Angiogenesis. VRAP was identified as an adaptor protein that binds the intracellular domain of KDR, recruiting cytoplasmic signaling proteins important for VEGF-induced endothelial cell survival and proliferation.
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