Key result
Beryllium fluoride induces specific structural changes in G- and F-actin, such as inhibiting tryptic and subtilisin digestions in subdomain 2, without significantly affecting actin-myosin interactions.
Population
G- and F-actin (in vitro models)
Design
Preclinical
Authors
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No immediate implications for myosin-based therapies; extends structural models of actin but leaves open physiological relevance.
Beryllium fluoride induces specific structural changes in G- and F-actin, highlighting the dynamic nature of actin structure and local differences between its monomeric and polymeric forms.
Mühlrád et al. (1994) studied Actin structural dynamics. Beryllium fluoride (BeFx) was evaluated on Structural and functional changes in G- and F-actin. Beryllium fluoride induces specific structural changes in G- and F-actin, such as inhibiting tryptic and subtilisin digestions in subdomain 2, without significantly affecting actin-myosin interactions.
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