Metastatic triple-negative breast cancer (TNBC) is a devastating disease with a historical median overall survival of approximately 17 months for all comers1 and up to 22 months for patients with germline BRCA mutations treated with PARP inhibitors.2 3 This patient population is also considered an unmet medical need due to the lack of effective targeted therapies (eg. endocrine or anti-HER2 therapies).
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Franzoi et al. (2020) studied this question.
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