Substantial effort has focused on the development of novel targeted agents for treating patients with late‐stage colorectal carcinoma. These agents are designed specifically to inhibit biochemical processes associated with pathogenesis. Numerous molecules targeting the epidermal growth factor receptor have been investigated as therapeutic agents and appear to herald a shift in the treatment paradigm for colorectal carcinoma. Cancer 2005.
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Alan P. Venook (2005) studied this question.
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