Key result
Genetic variations in over 40 genes, particularly nuclear envelope proteins, contribute to DCM cellular dysfunction.
Population
Patients with familial dilated cardiomyopathy
Design
Review
Authors
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May guide expanded genetic testing in familial DCM; leaves open functional validation of nuclear envelope variants.
This review highlights the growing number of genetic mutations, particularly in nuclear envelope proteins, associated with the pathogenesis of familial dilated cardiomyopathy.
Cho et al. (2016) conducted a review in Familial Dilated Cardiomyopathy. Genetic variations in over 40 genes, particularly those encoding nuclear envelope proteins, contribute to the complex etiology and cellular dysfunction of dilated cardiomyopathy.
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