Population
HeLa cells and in vitro biochemical models
Comparison
Expression of wild-type SEPT12 or SEPT12G56A… vs Wild-type SEPT12 vs SEPT12G56A mutant
Design
Preclinical
Authors
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Underscores SEPT12 GTPase dependence for cytoskeletal integrity; leaves open relevance to human disease models.
GTP binding is essential for SEPT12 to form filamentous structures and interact with SEPT11.
Ding et al. (2008) studied this question.
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