Key result
Recombinant human thrombopoietin induced tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and augmented ADP-induced platelet aggregation in a dose-dependent manner in vitro.
Population
Human platelets in vitro
Design
Preclinical
Authors
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May enhance platelet reactivity via JAK/STAT; leaves open clinical thrombotic relevance pending in vivo studies.
TPO modulates platelet activation through protein-tyrosine phosphorylation and enhances agonist-induced aggregation.
Ezumi et al. (1995) studied In vitro human platelets. Recombinant human thrombopoietin (TPO) was evaluated on Tyrosine phosphorylation and platelet aggregation. Recombinant human thrombopoietin induced tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and augmented ADP-induced platelet aggregation in a dose-dependent manner in vitro.
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