Key result
Systolic hypertension was associated with a 23% lower resting arterial-ventricular coupling (P=0.001) and a 61% lower coupling reserve (P<0.001) in women, but not in men.
Why the study?
Does systolic hypertension affect arterial-ventricular coupling at rest and during exercise differently in men and women?
Population
282 subjects, including normotensive (n=203) and systolic hypertension (brachial SBP >= 140 mmHg, n=79)
Comparison
Systolic hypertension and resting systolic blood… vs Normotensive subjects
Design
Cross-sectional
Authors
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Systolic hypertension may impair coupling reserve in women only; hypothesis-generating for sex differences, requires prospective confirmation.
Observational (n=282)
Does systolic hypertension affect arterial-ventricular coupling at rest and during exercise differently in men and women?
Effect estimate: 23% lower in women
p-value: p=0.001
Systolic hypertension is associated with lower resting arterial-ventricular coupling and attenuated coupling reserve in women, but not in men.
Chantler et al. (2008) conducted an observational in Systolic hypertension (n=282). Systolic hypertension vs. Normotensive was evaluated on Arterial-ventricular coupling (E(a)I/E(LV)I) at rest (23% lower in women, p=0.001). Systolic hypertension was associated with a 23% lower resting arterial-ventricular coupling (P=0.001) and a 61% lower coupling reserve (P<0.001) in women, but not in men.
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