Salivary salicylate concentrations were used to study the pharmacokinetics of a sustained release aspirin (SRA) in normal volunteers. The effect of fasting, food and metoclopramide were studied. Metoclopramide hastens absorption while a heavy meal delays absorption of SRA. The mean urinary recovery of aspirin in all the trials was 608 mg and the different treatments did not significantly alter urinary recovery.
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Brooks et al. (1978) studied this question.
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