Key result
EPS fails to differentiate arrhythmic event risk in drug-induced type-1 Brugada syndrome.
Why the study?
Risk stratification in drug-induced type-1 Brugada syndrome is challenging, and the role of electrophysiological study remains debated under current recommendations.
Does electrophysiological study aid prognostic stratification for arrhythmic events in patients with drug-induced type-1 Brugada syndrome?
Systematic Review (n=1,318)
Does electrophysiological study aid prognostic stratification for arrhythmic events in patients with drug-induced type-1 Brugada syndrome?
Electrophysiological study does not appear to aid in long-term prognostic stratification for arrhythmic events in patients with drug-induced type-1 Brugada syndrome.
EPS does not aid arrhythmic risk stratification in drug-induced type-1 Brugada syndrome; leaves open its utility in broader populations.
BACKGROUND: Risk stratification in drug-induced type-1 Brugada syndrome (BrS) patients is challenging. The role of electrophysiological study (EPS) is debated as the majority of drug-induced type-1 BrS patients would not be studied according to the latest recommendations. METHODS: A complete systematic literature search was performed to gauge the EPS role in this population. Three subgroups were defined: positive-EPS group, negative-EPS group, no-EPS group. RESULTS: Among 1318 drug-induced type-1 BrS patients, no significant difference in the incidence rate of arrhythmic events was observed between groups (I2 = 45%, P for subgroup difference = 0.10) during a mean follow-up of 5.1 years, also considering symptomatic status. CONCLUSION: In long-term follow-up of drug-induced type-1 BrS patients, EPS does not seem to aid prognostic stratification.
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Mascia et al. (2024) conducted a systematic review in Drug-induced type-1 Brugada syndrome (n=1,318). Electrophysiological study (EPS) vs. Negative-EPS or no-EPS was evaluated on Incidence rate of arrhythmic events (p=0.10). Electrophysiological study (EPS) did not significantly differentiate the incidence rate of arrhythmic events among drug-induced type-1 Brugada syndrome patients (P for subgroup difference = 0.10).
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