Key result
Rare pathogenic SCN5A variants are associated with more severe phenotypes in Brugada syndrome patients, potentially explained by greater epicardial arrhythmogenic substrates.
Why the study?
Are rare pathogenic SCN5A variants associated with more severe phenotypes in Brugada syndrome patients?
Are rare pathogenic SCN5A variants associated with more severe phenotypes in Brugada syndrome patients?
Rare pathogenic SCN5A variants in Brugada syndrome are linked to more severe clinical phenotypes, likely due to increased epicardial arrhythmogenic substrates.
The presence of rare pathogenic SCN5A variants is associated with more severe phenotypes in Brugada syndrome patients, which may be at least partly explained by greater epicardial arrhythmogenic substrates in these patients. The presence of rare pathogenic SCN5A variants is associated with more severe phenotypes in Brugada syndrome patients, which may be at least partly explained by greater epicardial arrhythmogenic substrates in these patients.
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Postema et al. (2020) conducted an editorial in Brugada syndrome. Rare pathogenic SCN5A variants was evaluated on Severe phenotypes. Rare pathogenic SCN5A variants are associated with more severe phenotypes in Brugada syndrome patients, potentially explained by greater epicardial arrhythmogenic substrates.
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