CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy

Caitlin M. Tilsed; Nicola Principe; Joel Kidman; Wee Loong Chin; M. Lizeth Orozco Morales; Rachael M. Zemek; Jonathan Chee; Rasa Islam; Vanessa S. Fear; Catherine A. Forbes; Wayne J. Aston; Maud H.E. Jansen; Abha Chopra; Timo Lassmann; Anna K. Nowak; Scott Fisher; Richard Lake; W. Joost Lesterhuis

doi:10.1016/j.celrep.2022.111874

Abstract

T cell-inflamed pre-treatment tumor microenvironment is necessary for response to chemotherapy, and this state can be therapeutically attained by targeted immunotherapy.

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Tilsed et al. (2022) studied this question.

synapsesocial.com/papers/6a0d0386a064aa35e1cc8efc https://doi.org/10.1016/j.celrep.2022.111874

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CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy

Abstract

Discussion

Cite This Study

CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy

Abstract

Discussion

Cite This Study

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