Key result
Review highlights LAA pathology and dysfunction parameters for predicting cryptogenic stroke risk.
Why the study?
Is left atrial appendage pathology and dysfunction associated with ischemic stroke risk in patients with unexplained or cryptogenic stroke?
Is left atrial appendage pathology and dysfunction associated with ischemic stroke risk in patients with unexplained or cryptogenic stroke?
This review highlights the potential role of left atrial appendage dysfunction parameters in predicting ischemic stroke risk, even in the absence of documented atrial fibrillation.
LAA parameters may aid cryptogenic stroke risk assessment; leaves open prospective validation before clinical use.
A bout 30% to 40% of ischemic stroke is of unknown cause. Recently, biomarkers of atrial dysfunction, or atrial cardiopathy, have been associated with embolic stroke risk even in the absence of atrial fibrillation (AF), suggesting that the presence of AF is not required for left atrial thromboembolism to occur. Most left atrial thrombi occur in the left atrial appendage (LAA), but there is limited use of LAA dysfunction parameters, such as LAA flow velocity and morphology, to predict ischemic stroke risk. Here we review the literature on the association between LAA pathology and dysfunction and ischemic stroke, with a focus on patients with unexplained, or cryptogenic, stroke.
No takes yet. Share an insight, caveat, or question.
Yaghi et al. (2015) conducted a review in Ischemic stroke. Left atrial appendage pathology and dysfunction assessment was evaluated on Ischemic stroke risk. About 30% to 40% of ischemic strokes are of unknown cause, prompting a review of left atrial appendage pathology and dysfunction parameters to predict cryptogenic stroke risk.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: