About 30% to 40% of ischemic strokes are of unknown cause, prompting a review of left atrial appendage pathology and dysfunction parameters to predict cryptogenic stroke risk.
A bout 30% to 40% of ischemic stroke is of unknown cause. Recently, biomarkers of atrial dysfunction, or atrial cardiopathy, have been associated with embolic stroke risk even in the absence of atrial fibrillation (AF), suggesting that the presence of AF is not required for left atrial thromboembolism to occur. Most left atrial thrombi occur in the left atrial appendage (LAA), but there is limited use of LAA dysfunction parameters, such as LAA flow velocity and morphology, to predict ischemic stroke risk. Here we review the literature on the association between LAA pathology and dysfunction and ischemic stroke, with a focus on patients with unexplained, or cryptogenic, stroke.
Yaghi et al. (Wed,) conducted a review in Ischemic stroke. Left atrial appendage pathology and dysfunction assessment was evaluated on Ischemic stroke risk. About 30% to 40% of ischemic strokes are of unknown cause, prompting a review of left atrial appendage pathology and dysfunction parameters to predict cryptogenic stroke risk.
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