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April 1, 1997Circulation

Verapamil Reduces Tachycardia-Induced Electrical Remodeling of the Atria

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Why the study?

Does verapamil reduce tachycardia-induced electrical remodeling of the atria in a goat model of rapid atrial pacing?

Population

5 chronically instrumented conscious goats undergoing 24 hours of rapid atrial pacing (300 bpm)

Comparison

Verapamil infusion vs Saline infusion (control)

Design

Preclinical

Follow-up

24 hours

Authors

RTRobert G TielemanCLCees D. J. de LangenIGIsabelle C. Van Gelder

Discussion

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Overview

Supports calcium-dependent atrial remodeling; hypothesis-generating for verapamil in human AF prevention.

Structured PICO

Does verapamil reduce tachycardia-induced electrical remodeling of the atria in a goat model of rapid atrial pacing?

P
Population
5 chronically instrumented conscious goats undergoing 24 hours of rapid atrial pacing (300 bpm)
I
Intervention
Verapamil infusion
C
Comparator
Saline infusion (control)
O
Outcome
Shortening of the atrial effective refractory period (AERP) measured by programmed electrical stimulation at basic cycle lengths of 430, 300, and 200 mssurrogate

Verapamil significantly attenuates tachycardia-induced atrial electrical remodeling in a goat model, suggesting that calcium influx triggers this process.

Cite This Study

Tieleman et al. (1997) studied this question.

synapsesocial.com/papers/6a0d28fdd7cdc72b86656664https://doi.org/10.1161/01.cir.95.7.1945
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