Key result
Streamlining sinus rhythm activation with >4 RFA lines best terminates pAF in silico.
Why the study?
Do novel radiofrequency ablation strategies guided by phase singularity mapping or streamlining activation sequences terminate persistent atrial fibrillation in a computer model?
Population
Bilayer computer model of the human atria with persistent AF electrical and structural remodeling.
Design
Preclinical
Authors
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May guide ablation lesion planning in persistent AF; leaves open clinical translation pending human trials.
Do novel radiofrequency ablation strategies guided by phase singularity mapping or streamlining activation sequences terminate persistent atrial fibrillation in a computer model?
In a computer model of persistent AF, co-localizing 1.5 cm RFA lesions with locations of high phase singularity density or streamlining activation sequences during sinus rhythm effectively terminated AF rotors.
Bayer et al. (2016) studied Persistent Atrial Fibrillation (pAF). Novel radiofrequency ablation (RFA) strategies (circles, lines, crosses, streamlining activation) vs. Standard PVI, roof, and mitral lines was evaluated on Termination of simulated persistent atrial fibrillation (pAF) rotors. In an in silico model of persistent atrial fibrillation, streamlining the sequence of activation during sinus rhythm with >4 RFA lines was the most effective strategy for terminating pAF.
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