Key result
A physiologically steep slope of the electrical restitution curve, rather than a flat slope, is proposed as a better design against arrhythmias by allowing faster action potential duration recovery.
This review challenges the notion that flattening the electrical restitution curve is antiarrhythmic, arguing instead that a steep initial slope is a better physiological defense against arrhythmias.
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Challenges view of flat restitution slopes as antiarrhythmic; hypothesis-generating for arrhythmia prevention strategies.
Michael R. Franz (2003) conducted a review in Arrhythmias. Electrical restitution curve slope vs. Flat slope was evaluated. A physiologically steep slope of the electrical restitution curve, rather than a flat slope, is proposed as a better design against arrhythmias by allowing faster action potential duration recovery.
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