Key result
Calcium-bound DREAM/KChIP3 interacts with calmodulin with a dissociation constant of 3 µM, enhancing calmodulin-dependent calcineurin activity.
Population
In vitro biochemical models using neuronal proteins to study DREAM/KChIP3 interactions
Comparison
DREAM/KChIP3 vs Absence of calcium, or absence of DREAM/KChIP3
Design
Preclinical
Authors
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Does not support clinical translation; hypothesis-generating for DREAM's role in cardiac calcineurin signaling.
DREAM/KChIP3 heterodimerizes with calmodulin in a calcium-dependent manner, which enhances calmodulin-dependent calcineurin activity.
Ramachandran et al. (2012) studied this question. DREAM/KChIP3 was evaluated on Protein interaction and calcineurin activity. Calcium-bound DREAM/KChIP3 interacts with calmodulin with a dissociation constant of 3 µM, enhancing calmodulin-dependent calcineurin activity.
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