Key result
Angiotensin II negatively modulates cytokine-induced nitric oxide production by blocking iNOS expression via the AT1 receptor in vascular smooth muscle cells.
Why the study?
Does Angiotensin II inhibit cytokine-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells?
Population
Cultured vascular smooth muscle cells (VSMC)
Comparison
Angiotensin II in the presence of inflammatory… vs Inflammatory cytokines alone
Design
Preclinical
Authors
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Does not support clinical changes to AT1 blockade; leaves open relevance to human vascular inflammation.
Does Angiotensin II inhibit cytokine-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells?
Angiotensin II negatively modulates cytokine-induced NO production by blocking iNOS expression via the AT1 receptor in vascular smooth muscle cells, potentially involving protein kinase C.
Nakayama et al. (1994) studied In vitro study (vascular smooth muscle cells). Angiotensin II vs. IL-1 beta or TNF-alpha alone was evaluated on Nitrite production and iNOS mRNA and protein levels. Angiotensin II negatively modulates cytokine-induced nitric oxide production by blocking iNOS expression via the AT1 receptor in vascular smooth muscle cells.
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