Emergency PCI for stent thrombosis was successful in 91% of cases, and achieving TIMI 3 flow independently reduced the risk of cardiac death (OR 0.1; 95% CI 0.01-0.54; P<0.001).
Cohort (n=95)
Does emergency percutaneous coronary intervention improve outcomes in patients with stent thrombosis following bare-metal stent implantation?
Emergency PCI for stent thrombosis is highly successful in restoring vessel patency, and achieving optimal angiographic results (TIMI 3 flow and <50% residual stenosis) significantly reduces the risk of cardiac death, though patients remain at high risk for recurrent events.
AIMS: To investigate the efficacy and outcome of emergency percutaneous coronary interventions (PCI) in patients with stent thrombosis. METHODS AND RESULTS: Between 1995 and 2003, 6058 patients underwent bare-metal stent implantation, of which 95 (1.6%) patients suffered from stent thrombosis. The timing of stent thrombosis was acute in 10 (11%), subacute in 61 (64%), and late in 24 (25%) patients. Procedural and clinical outcomes of emergency PCI for treatment of stent thrombosis were investigated. Emergency PCI was successful in 86 (91%), complicated by death in 2 (2%), and coronary artery bypass grafting in 2 (2%) patients. Myocardial infarction occurred in 77 (81%) patients with a peak creatine kinase level of 1466+/-1570 U/L. Left ventricular ejection fraction declined from 0.54+/-0.19 prior to 0.48+/-0.16 (P<0.05) at the time of stent thrombosis after emergency PCI. A 6 month major adverse clinical events comprised death (11%), reinfarction (16%), and recurrent stent thrombosis (12%) after emergency PCI. Multivariable logistic regression analysis identified the achievement of TIMI 3 flow (OR=0.1, CI 95% 0.01-0.54, P<0.001) and diameter stenosis <50% (OR=0.06, CI 95% 0.01-0.32, P<0.001) during emergency PCI to be independently associated with a reduced risk of cardiac death. Recurrent stent thrombosis was independently predicted by the omission of abciximab (OR=4.3, CI 95% 1.1-17.5). CONCLUSION: Emergency PCI for treatment of stent thrombosis effectively restores vessel patency and flow. Patients presenting with stent thrombosis are at risk for recurrent myocardial infarction and recurrent stent thrombosis.
Wenaweser et al. (2005) conducted a cohort in Stent thrombosis following bare-metal stent implantation (n=95). Emergency percutaneous coronary intervention (PCI) was evaluated on Procedural success. Emergency PCI for stent thrombosis was successful in 91% of cases, and achieving TIMI 3 flow independently reduced the risk of cardiac death (OR 0.1; 95% CI 0.01-0.54; P<0.001).