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May 20, 2026American Journal of Respiratory and Critical Care Medicine

C56-25 Intensivist Led Code Sepsis Team, and Impact on Sep-1 Bundle Compliance, and Sepsis Mortality - A Retrospective Cohort Comparison Study

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Authors

RMR P ManglaniRRR RandaMHM Hammad

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Overview

Retrospective comparison shows improved sepsis outcomes and bundle compliance with interdisciplinary approach.

Key Points

  • This study investigates the effects of a multi-disciplinary intensivist-led team on sepsis mortality and SEP-1 bundle compliance.
  • Formed a multi-disciplinary team including an Intensivist, Pharmacist, and Nurse to respond to 'SEPSIS CODE' within an hour.
  • Defined sepsis based on SIRS criteria or elevated lactic acid levels for patient assessment.
  • Analyzed sepsis outcomes and bundle compliance over time compared to other hospitals within the system.
  • Sepsis mortality trended downward in the index hospital prior to the intervention, with some increases during the COVID pandemic.
  • Improvements in SEP-1 bundle compliance observed over time post-intervention.
  • Linear regression analysis indicates positive trends in sepsis outcomes associated with the 'CODE SEPSIS' initiative.

Cite This Study

Manglani et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4ee2f03e14405aa9a162https://doi.org/10.1093/ajrccm/aamag162.6254
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