Among hospitalized patients with asthma, the incidence of inpatient VTE was 31.3%, and non-ICU admission was associated with higher odds of developing DVT alone versus both DVT and PE (OR 5.85; 95% CI 1.41-29.98).
Cohort (n=326)
No
Hospitalized patients with asthma demonstrate a high incidence of inpatient VTE (31.3%), highlighting a potentially increased thrombotic burden in this population, particularly among those requiring ICU care.
Abstract Rationale Asthma is characterized by chronic airway inflammation and remodeling. Previous studies have demonstrated an increased incidence of venous thromboembolism (VTE) in patients with asthma which may be secondary to a bidirectional relationship between inflammatory and coagulation pathways. This retrospective cohort study assesses incidence and factors associated with development of VTE in hospitalized patients with asthma. Methods Patients (≥ 18 years old) who were admitted for any cause to a tertiary care medical center between January 2024 and January 2025 with an ICD-10 code diagnosis of asthma in their electronic medical record were included in the study. Records were reviewed for demographics, imaging-diagnosed pulmonary embolism (PE) or deep vein thrombosis (DVT), time from admission to VTE event, length of stay, level of care, and prothrombotic history. Results Among 326 patients, 102 (31.3%) experienced an inpatient VTE. 40% developed a PE, 50% a DVT, and 10% both. Mean age was 74.5 (SD ± 2.1) years, and 69.6% were female. Mean hospitalization length was 7.0 (SD ± 4.2) days, and mean time from admission to VTE was 5.0 (SD ± 3.5) days. Female patients had higher rates of DVT (59.2%) and PE (54.9%) than males (54.8% and 48.4%). Both patients with prior VTE (19.6%) and history of malignancy (18.6%) had higher rates of DVT (63.2% and 73.7%) than PE (47.4% and 36.8%). One-third of patients were admitted to the intensive care unit (ICU) and had a higher rate of DVT (73.5%) than PE (28.3%). Logistic regression showed no significant association between age (p=.09), sex (p=.71), malignancy (p=.18), prior VTE (p=.45), or length of stay (p=.05) in developing DVT versus PE. However, there was a statistically significant association in incidence of DVT alone rather than both DVT and PE in non-ICU patients (OR 5.85, 95% CI 1.41–29.98, p=.034). Conclusions The incidence of VTE in this study (31.3%) was higher than the average reported incidence of hospital-acquired VTE (1-1.3%). No significant demographic or clinical predictors were identified for the VTE subtype patients developed. Patients with asthma who were admitted to the ICU were more likely to have both a DVT and PE which suggests increased thrombotic burden in this population. Future studies are needed to better understand and characterize the increased inpatient VTE risk in patients with asthma. This abstract is funded by: None
Fatima et al. (Fri,) conducted a cohort in Asthma (n=326). Among hospitalized patients with asthma, the incidence of inpatient VTE was 31.3%, and non-ICU admission was associated with higher odds of developing DVT alone versus both DVT and PE (OR 5.85; 95% CI 1.41-29.98).