Abstract Introduction Sarcoidosis is a systemic inflammatory disease histologically characterized by non-caseating granulomas that is associated with decreased health-related quality of life and increased mortality compared with the healthy population (Sharp et al, 2020). Clinical presentation and outcomes of sarcoidosis vary by gender, race, and geographical location, in part due to socioeconomic population differences. The demographics and characteristics of sarcoidosis patients treated in Colorado, however, have not been described. Methods This is a retrospective, exploratory study of patients seen at the University of Colorado Hospital between 2010-2025 with an ICD-10 code for sarcoidosis. For this population, we gathered data from the electronic health record (Epic Systems Corporation, UCHealth) related to demographics, immunosuppressant medications prescribed, hospital admissions including length of stay, and Elixhauser Comorbidity Index. We generated descriptive statistics on these variables with specific focus on the variables broken down by race. Results We identified 7178 patients seen at the University of Colorado Hospital with an ICD-10 code for sarcoidosis. 4977 (69.3%) identified as White, 1079 (15.0%) as Black or African American, 553 (7.7%) as Hispanic/Latino, 14 (0.2%) as Asian, and 555 (7.7%) as another race. The mean Elixhauser Comorbidity Index was 6.2±4.6. The mean number of immunosuppressant medications prescribed to each patient was 1.1±1.1, with the most common medication being prednisone (n = 4244, 59.1%) followed by methotrexate (n = 1074, 15.0%) and mycophenolate (n = 387, 5.4%). 2077 patients (30.7%) received no medication. The mean number of emergency department (ED) visits, hospital admissions, and intensive care unit (ICU) admissions per patient was 3.0, 1.4, and 0.2, respectively. Black patients received, on average, a greater number of medications (1.2±1.1) and had an increased mean number of ED, hospital, and ICU admissions (5.5±9.0, 2.9±4.3, and 2.3±4.4) when compared with the population mean. Conclusion Sarcoidosis disproportionately impacts patients at University of Colorado Hospital who identify as Black, aligning with prior reviews establishing health disparities in sarcoidosis. Further research is needed to better understand the drivers behind this disparity and to identify opportunities for patient- and system-level interventions to improve health outcomes. This abstract is funded by: None
McKee et al. (Fri,) studied this question.