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May 20, 2026International Journal of Critical Illness and Injury Science

Evaluating the role of high-dose intravenous thiamine supplementation for lactate clearance in patients with cirrhosis and sepsis

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Authors

RARadiya AliAYANGEL YAZDIKCKeegan Collins

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Overview

Retrospective cohort study evaluates thiamine's effect on lactate clearance in cirrhosis patients with sepsis, suggesting limited benefit.

Key Points

  • To determine the effect of high-dose intravenous thiamine on lactate clearance in patients with cirrhosis and sepsis.
  • Single-center retrospective cohort study of critically ill patients with cirrhosis and sepsis with lactate >4 mmol/L
  • Patients receiving ≥400 mg of thiamine classified as high-dose
  • Fine-Gray competing risks models were used to estimate associations with time to lactate clearance.
  • 136 patients were analyzed, median age 58.4, 54% male, 33 received high-dose thiamine.
  • No association was found between high-dose thiamine and time to lactate clearance (p-value not specified).
  • Mortality rates did not differ between thiamine and non-thiamine groups (details not provided).

Cite This Study

Ali et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4f7bf03e14405aa9acafhttps://doi.org/10.4103/ijciis.ijciis_124_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of thiamine (vitamin B1) in sepsis and septic shock: A meta-analysis of randomized controlled trials2026 · 3 citations
  2. 2Thiamine supplementation is associated with lower in-hospital and ICU mortality in patients with acute respiratory failure: a retrospective cohort study based on the MIMIC-IV database2026
  3. 3Association of thiamine supplementation with 30-day mortality among ICU patients with sepsis-associated delirium2026
  4. 4870: LACTATE CLEARANCE IN PATIENTS WITH LIVER CIRRHOSIS AND SEPSIS2026
  5. 5Thiamine Therapy During Refractory Lactic Acidosis in Critically Ill Children2024