Design, synthesis, antimicrobial and antioxidant evaluation, cytotoxicity assessment, and molecular dynamics-based computational studies of novel PABA analogues as dual DHPS/DHFR inhibitors

Bhargav Devliya; Ahmed K. Al-Kubeisi; Drashti Patel; Milan Dabhi; Bimalkumar Patel; Milan Thakar; Jaykumar Nagapara; Shreya Chauhan; Kiransinh Rajput; Dweipayan Goswami; Nandan Dixit; Saumya Patel; Gaurang Sindhav; Botros Y. Beshay; Hitesh D. Patel

doi:10.1039/d6ra01925k

January 1, 2026RSC AdvancesOpen Access

Design, synthesis, antimicrobial and antioxidant evaluation, cytotoxicity assessment, and molecular dynamics-based computational studies of novel PABA analogues as dual DHPS/DHFR inhibitors

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Key Points

The aim is to develop new PABA-based hybrids that act as dual inhibitors of DHPS and DHFR.
Synthesis of novel PABA-based compounds.
Evaluation of antimicrobial activity against resistant strains.
Computational studies using molecular dynamics and cytotoxicity assessments.
These PABA analogues displayed significant antimicrobial activity against resistant strains.
Computational studies supported their potential as DHPS/DHFR inhibitors.

Implication

Novel PABA-based compounds exhibit antimicrobial activity against resistant strains, indicating potential therapeutic applications.

Abstract

Novel PABA-based hybrids were developed as dual DHPS/DHFR inhibitors, showing promising antimicrobial activity against resistant strains supported by experimental and computational studies.

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Cite This Study

Devliya et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4f92f03e14405aa9add0 https://doi.org/10.1039/d6ra01925k

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Design, synthesis, antimicrobial and antioxidant evaluation, cytotoxicity assessment, and molecular dynamics-based computational studies of novel PABA analogues as dual DHPS/DHFR inhibitors

Key Points

Implication

Abstract

Discussion

Cite This Study

Design, synthesis, antimicrobial and antioxidant evaluation, cytotoxicity assessment, and molecular dynamics-based computational studies of novel PABA analogues as dual DHPS/DHFR inhibitors

Key Points

Implication

Abstract

Discussion

Cite This Study

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