B45-01 Clinical Outcomes of Patients With Non-Cystic Fibrosis Bronchiectasis

Abstract Introduction Bronchiectasis is the permanent dilation of the airways. The widespread use of high-resolution computed tomography is likely the main factor related to the increased diagnosis. Therefore, we aimed through this study to analyze the profile and clinical outcomes of patients with non-cystic fibrosis bronchiectasis at a tertiary center in the state of Goiás. Methods A retrospective, single-center cohort study was conducted to evaluate the profile of patients with non-cystic fibrosis bronchiectasis followed at a tertiary hospital. Sociodemographic data, comorbidities, symptoms, medications in use, spirometric data, sputum culture analysis, and the number of exacerbations and hospitalizations were collected from medical records with the help of the artificial intelligence Gemini AI PRO 2.5 (MOUNTAIN VIEW:GOOGLE 2025). After collection, the entered data was manually checked for potential adjustments. Data normality was tested using the Shapiro-Wilk test. Comparisons between groups were performed using the Mann-Whitney and Kruskal-Wallis tests. Associations between categorical variables were investigated using the chi-square test. A p-value 0.05 was considered statistically significant. Results Data was collected from the medical records of 75 patients followed at the hospital’s non-cystic fibrosis bronchiectasis outpatient clinic. The mean age was 58.12 years, with a predominance of women (74.7%). The distribution of etiologies is presented in Table 1.Most of the evaluated stratifications showed no significant differences in the number of exacerbations or hospitalizations (χ² = 1.13-6.01; p 0.05). However, continuous use of azithromycin was associated with a reduction in the number of exacerbations compared to the use of saline solution (χ² = 7.89; df = 1; p = 0.005). Sputum culture positivity was not associated with sputum color (χ² = 3.77; p = 0.288), but chronic infection showed a significant association with yellow or green coloration (χ² = 8.72; df = 3; p = 0.033). Conclusion A predominance of post-infectious etiology is observed in these patients. Although the evaluation of etiology alone as a predictor of severity was not demonstrated in the study, the continuous use of azithromycin was associated with a reduced number of exacerbations. This abstract is funded by: None