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May 20, 2026American Journal of Respiratory and Critical Care Medicine

D109-12 A Systematic Review and Meta-Analysis of Sotatercept’s Efficacy and Safety in Pulmonary Arterial Hypertension

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Authors

MAM AkkawiAAA AlnimerMEM Elkholy

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Overview

Systematic review evaluates sotatercept's efficacy in pulmonary arterial hypertension, suggesting potential benefits despite no mortality reduction.

Key Points

  • This review aims to evaluate the efficacy and safety of sotatercept in treating pulmonary arterial hypertension (PAH).
  • Conducted a systematic review and meta-analysis following PRISMA guidelines.
  • Evaluated randomized controlled trials comparing sotatercept with placebo in adults with PAH.
  • Included a total of 921 patients from four major trials.
  • No significant difference in all-cause mortality between sotatercept and placebo (OR 0.65, 95% CI 0.34-1.24, p = 0.19).
  • Sotatercept significantly improved six-minute walk distance by +30.4 m (95% CI 14.2-46.7, p = 0.0002).
  • Reduced the risk of PAH-related hospitalization or clinical worsening (OR 0.17, 95% CI 0.07-0.4, p < 0.001).

Cite This Study

Akkawi et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fbff03e14405aa9b2fchttps://doi.org/10.1093/ajrccm/aamag162.5912
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