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May 20, 2026American Journal of Respiratory and Critical Care Medicine0 citations

Correlation of Genotypic and Phenotypic Tests for Rifampicin-Resistant Tuberculosis

B69-11 Correlation Between Genotypic and Phenotypic Tests in the Detection of Rifampicin-Resistant Mycobacterium Tuberculosis

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Authors

NCN ChiracharaspornTST SanchatPSP Sangsayunh

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Overview

Retrospective study evaluates rifampicin resistance detection methods in drug-resistant tuberculosis, indicating promising genotypic testing reliability.

Key Points

  • To evaluate the agreement between genotypic testing using Xpert MTB/RIF Ultra and phenotypic drug susceptibility testing results for rifampicin-resistant tuberculosis.
  • Retrospective study at the Central Chest Institute of Thailand involving 217 patients with RR-TB and MDR-TB.
  • Sputum samples assessed for rifampicin resistance using both Xpert MTB/RIF Ultra and phenotypic DST methods.
  • Statistical analysis of concordance performed using STATA software version 15.1.
  • Of 87 isolates analyzed, the agreement between Xpert MTB/RIF Ultra and phenotypic DST results was 88.88%.
  • 48 isolates were phenotypically rifampicin-resistant, while 6 were susceptible.
  • Moderate to excellent agreement for rpoB genes, except for rpoB1, which had 50% concordance.

Cite This Study

Chiracharasporn et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fd2f03e14405aa9b572https://doi.org/10.1093/ajrccm/aamag162.6734
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