Randomized trial examines how surfactant protein A modulates responses to influenza A in asthma, suggesting therapeutic potential.
Key Points
The central aim is to explore how surfactant protein A influences epigenetic changes and transcriptional responses to influenza A virus in individuals with asthma.
Primary bronchial epithelial cells from asthmatic and non-asthmatic individuals were collected via bronchoscopy.
Cells were treated with surfactant protein A and subsequently infected with influenza A virus for analysis.
Genome-wide DNA methylation profiling and bulk RNA sequencing were performed to analyze responses.
Non-asthmatic samples showed an enriched response to viral infection (FDR = 9.0 × 10−5), while asthmatic samples were enriched for cytokine response (FDR = 5.9 × 10−3).