Right ventricular systolic function measured by TAPSE showed a significant positive correlation with FEV1% (r=0.413, p=0.0001), with RV dysfunction present in 53.85% of GOLD 4 patients.
Cross-Sectional (n=70)
Right ventricular systolic dysfunction measured by TAPSE is highly prevalent in severe COPD and correlates significantly with declining lung function.
Effect estimate: r = 0.413
p-value: p=0.0001
Abstract Rationale Right ventricular (RV) systolic dysfunction is a critical complication of COPD that is associated with a worse prognosis. Tricuspid Annular Plane Systolic Excursion (TAPSE) is a simple, reliable echocardiographic measure of RV systolic function. We aimed to assess the prevalence of RV dysfunction using TAPSE and correlate it with the severity of airflow obstruction in patients with COPD. Methods We conducted a cross-sectional study of 70 patients with spirometry-confirmed COPD (post-BD FEV1/FVC 0.7). Patients were staged according to GOLD 2023 guidelines based on post-bronchodilator FEV1%. Transthoracic echocardiography was performed to measure TAPSE, with RV systolic dysfunction defined as TAPSE 1.7 cm. The association between mean TAPSE and GOLD stage was analyzed using ANOVA, and the correlation with FEV1% was assessed using Pearson correlation. Results The 70-patient cohort (mean age 62.3) included 41.4% GOLD 2, 40.0% GOLD 3, and 18.6% GOLD 4.• Mean TAPSE: A significant progressive decline in mean TAPSE was observed with worsening GOLD stage: 2.18 ± 0.26 cm (GOLD 2), 2.08 ± 0.35 cm (GOLD 3), and 1.72 ± 0.3 cm (GOLD 4) (p = 0.0001).• Prevalence of RV Dysfunction: Overall, 17.1% of patients had reduced TAPSE ( 1.7 cm). The prevalence was dramatically higher in patients with very severe disease: 53.85% of GOLD 4 patients had RV dysfunction, compared to 14.29% of GOLD 3 and only 3.45% of GOLD 2 patients (p = 0.0005).• Correlation: TAPSE demonstrated a significant positive correlation with FEV1% (r = 0.413, p = 0.0001), indicating that as lung function declines, RV function also declines. Conclusion Right ventricular systolic dysfunction, measured by TAPSE, is highly prevalent in patients with very severe COPD, affecting over half of this group. The significant correlation between declining TAPSE and worsening FEV1% underscores the value of echocardiography in identifying RV dysfunction in patients with advanced airflow obstruction. This abstract is funded by: No funding required
Shah et al. (Fri,) conducted a cross-sectional in COPD (n=70). Echocardiography (TAPSE) was evaluated on Correlation between TAPSE and FEV1% (r = 0.413, p=0.0001). Right ventricular systolic function measured by TAPSE showed a significant positive correlation with FEV1% (r=0.413, p=0.0001), with RV dysfunction present in 53.85% of GOLD 4 patients.