Key result
High Life's Essential 8 score linked to ~35% lower cognitive impairment prevalence vs low score.
Why the study?
The American Heart Association's Life's Essential 8 framework has been linked to cognitive impairment, but evidence in Chinese older adults remains limited.
Does a high Life's Essential 8 score reduce the risk of cognitive impairment in older adults?
Cross-Sectional (n=7,469)
Does a high Life's Essential 8 score reduce the risk of cognitive impairment in older adults?
Optimal cardiovascular health, as measured by the Life's Essential 8 framework, is associated with a lower prevalence of cognitive impairment and attenuates genetic risk in older Chinese adults.
INTRODUCTION The American Heart Association's Life's Essential 8 (LE8) framework has been linked to cognitive impairment, but evidence in Chinese older adults remains limited. METHODS This cross‐sectional study included 7469 adults aged ≥60 years from the West China Health and Aging Cohort. Modified Poisson regression with robust error variance was used to examine the associations of LE8 scores and genetic risk, as well as their joint associations, with cognitive impairment. RESULTS Compared with the low LE8 score group, the high LE8 score group had a prevalence ratio (PR) of 0.65 (95% confidence interval [CI]: 0.56 to 0.76) for cognitive impairment. A joint association was observed between LE8 and genetic risk, with the highest PR of 1.19 (95% CI: 1.12 to 1.27) in the low LE8 and high‐genetic‐risk group. DISCUSSION Optimal cardiovascular health was associated with lower cognitive impairment and attenuation of genetic risks among older adults in western China.
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Wang et al. (2026) conducted a cross-sectional in cognitive impairment (n=7,469). Life's Essential 8 (LE8) score vs. Low LE8 score was evaluated on cognitive impairment (PR 0.65, 95% CI 0.56 to 0.76). A high Life's Essential 8 score was associated with a lower prevalence of cognitive impairment compared to a low score (PR 0.65; 95% CI 0.56-0.76) among older adults in western China.
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