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May 20, 2026American Journal of Respiratory and Critical Care Medicine0 citations

End-Tidal Alveolar Dead Space Fraction and Delirium in Children With Acute Respiratory Distress...

A26-02 End-tidal Alveolar Dead Space Fraction and Psychiatric Diagnosis of Delirium in Children With Acute Respiratory Distress Syndrome

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Authors

ERE RinaldiBOB A OlosoMKM J Klein

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Overview

Secondary analysis finds no association between end-tidal alveolar dead space and delirium in children with acute respiratory distress syndrome, suggesting under-recognition.

Key Points

  • This analysis aims to investigate the relationship between end-tidal alveolar dead space fraction and delirium in children with acute respiratory distress syndrome.
  • Secondary analysis of children with pediatric acute respiratory distress syndrome enrolled in a randomized controlled trial.
  • Assessment of end-tidal alveolar dead space fraction and oxygenation index during the first 24 hours of invasive mechanical ventilation.
  • Psychiatric diagnosis of delirium was the primary outcome assessed within 21 days of ventilation initiation.
  • 27 out of 205 children diagnosed with delirium (13%) after a median of 7 days from ventilation initiation.
  • Neither median end-tidal alveolar dead space fraction nor oxygenation index was associated with delirium diagnosis.
  • Children with moderate neurologic impairment represented a lower likelihood of delirium diagnosis (OR 0.26, 95% CI [0.08, 0.82], p = 0.021).

Cite This Study

Rinaldi et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5051f03e14405aa9c0dahttps://doi.org/10.1093/ajrccm/aamag162.019
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