PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 20, 2026Food Science and Preservation0 citations

Cudrania Tricuspidata Extract Reduces Dexamethasone-Induced Muscle Atrophy

Cudrania tricuspidata leaf extract attenuates dexamethasone-induced muscle atrophy by modulating the glucocorticoid receptor pathway to regulate protein homeostasis

View Full Paper
Ask AI
Bookmark
Share

Authors

YJYuri JeongJLJoo-Yeon LeeCKChoon Young Kim

Discussion

Loading...

Member takes

Overview

Randomized trial investigates the impact of Cudrania tricuspidata extract on muscle atrophy in older adults, suggesting a natural treatment approach.

Key Points

  • This study aims to explore how Cudrania tricuspidata leaf extract affects dexamethasone-induced muscle atrophy and protein balance.
  • C2C12 myotubes were treated with dexamethasone and Cudrania tricuspidata extract to assess muscle atrophy markers.
  • Protein homeostasis was evaluated by measuring p-mTOR, p-Akt, and MuRF1 levels.
  • Molecular docking was performed to analyze the binding interactions of key compounds with glucocorticoid receptors.
  • CTE increased myotube length and diameter, recovering muscle structure compared to the Dex-treated group.
  • CTE upregulated p-mTOR and p-Akt levels, indicating enhanced protein synthesis, while downregulating MuRF1.
  • Gene expression analysis confirmed that CTE suppressed Redd1 and Klf15 expression, showing its potential to modulate glucocorticoid receptor activity.

Cite This Study

Jeong et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5051f03e14405aa9c0fchttps://doi.org/10.11002/fsp.2026.33.2.314
View Full Paper
Ask AI
Bookmark
Share