Demonstrates a novel benzylation method using photoredox and nickel catalysis, indicating practical applications.
) bond formation under mild conditions without preformed organometallic reagents. Upon photoirradiation, these precursors generate benzyl radicals via double decarboxylation, selectively reacting with electron-rich aryl bromides. Electron-deficient aryl bromides yield hydroxylated products. Mechanistic studies support a radical pathway. This strategy offers a practical, operationally simple approach for aryl halide benzylation under dual photoredox/nickel catalysis.
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Lin et al. (2026) studied this question.
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