C77-21 Distinct Prognostic Role of ALK Fusion in Early and Advanced-Stage Lung Adenocarcinomas Stratified by Clinicopathologic and Radiologic Features

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Key Points

This research aims to investigate the prognostic implications of ALK fusion in lung adenocarcinoma, considering stage and histologic characteristics.
Retrospective study of resected lung adenocarcinoma patients from 2008 to 2020 with ALK examination.
Exclusion of patients who received tyrosine kinase inhibitors for survival analysis.
Categorized cases by stage, tumor type, differentiation, and aggressiveness for comparing outcomes based on ALK status.
In a cohort of 2766 cases, 4.8% were ALK-positive, linked to advanced stage and aggressive characteristics.
ALK fusion correlated with reduced recurrence-free survival in early-stage and less aggressive groups.
In advanced-stage, ALK positivity provided significant survival benefits with adjuvant chemotherapy.

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Retrospective analysis reveals ALK fusion impacts survival in early-stage lung adenocarcinoma, suggesting a need for targeted management strategies.

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Ma et al. (2026) studied this question.

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