On-demand dopamine receptor activation via photoresponsive nanoparticle-dopamine conjugates in differentiated SH-SY5Y and transfected HEK293 cells

Hajar Alghamdi; Sunil Rajput; Noah Russell; Shailesh Mistry; Charles A. Laughton; Giuseppe Mantovani; Pavel Gershkovich; Keith Spriggs; Mischa Zelzer

doi:10.1039/d6ma00037a

January 1, 2026Materials AdvancesOpen Access

On-demand dopamine receptor activation via photoresponsive nanoparticle-dopamine conjugates in differentiated SH-SY5Y and transfected HEK293 cells

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Key Points

This research aims to investigate on-demand dopamine receptor activation using nanoparticle-dopamine conjugates in cellular models relevant to Parkinson's Disease.
Utilized photoresponsive nanoparticle-dopamine conjugates for targeted receptor activation
Conducted experiments on differentiated SH-SY5Y cells and transfected HEK293 cells
Assessed receptor activities under varying light conditions
Demonstrated successful receptor activation in SH-SY5Y and HEK293 cells
Confirmed higher dopamine availability correlated with increased receptor response
Found significant variations in activation efficiency based on light exposure conditions

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Implication

Explores dopamine receptor activation in SH-SY5Y and HEK293 cells, highlighting potential Parkinson's treatment strategies.

Abstract

Parkinson’s Disease is a complex neurodegenerative disease associated with the reduction of dopamine content in the brain. Dopamine, in the form of the precursor L-DOPA, is used as a replacement...

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Cite This Study

Alghamdi et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5098f03e14405aa9c801 https://doi.org/10.1039/d6ma00037a

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On-demand dopamine receptor activation via photoresponsive nanoparticle-dopamine conjugates in differentiated SH-SY5Y and transfected HEK293 cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

On-demand dopamine receptor activation via photoresponsive nanoparticle-dopamine conjugates in differentiated SH-SY5Y and transfected HEK293 cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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