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A41-20 Cetuximab-Induced Pneumonitis in a Patient With Metastatic Cutaneous Squamous Cell Carcinoma: A Rare and Fatal Complication

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Case presentation reveals fatal pneumonitis in a patient with cutaneous SCC, highlighting early recognition's importance.

To report a rare case of cetuximab-induced pneumonitis in a patient with metastatic cutaneous SCC and its clinical implications.
Described a case of a 75-year-old male with metastatic cutaneous SCC and progressive respiratory symptoms after cetuximab treatment.
Conducted extensive infectious workup including respiratory viral and atypical pathogen panels, which were negative.
Administered high-dose intravenous methylprednisolone following suspicion of drug-induced pneumonia.
The patient developed severe respiratory distress two weeks post-cetuximab introduction, confirming suspected cetuximab-induced pneumonitis.
Chest imaging showed bilateral interstitial opacities consistent with acute pneumonitis.
Despite corticosteroid treatment, the patient opted for comfort care due to deteriorating health.

Martini et al. (2026) studied this question.

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