What question did this study set out to answer?

To highlight the diagnostic difficulties in disseminated tuberculosis and the complications arising from isoniazid treatment.

A70-28 Hard to Diagnose, Harder to Treat: A Case of Culture-Delayed Disseminated Tuberculosis Complicated by Isoniazid Neurotoxicity

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To highlight the diagnostic difficulties in disseminated tuberculosis and the complications arising from isoniazid treatment.
Case report of a 66-year-old female with end-stage renal disease and suspected disseminated TB.
Utilized diagnostics including CT scans, lymph node biopsies, and fluid analyses for diagnoses.
Monitored treatment outcomes and complications related to isoniazid therapy.
The patient was ultimately diagnosed with disseminated TB after initial negative tests and later culture positive for Mycobacterium tuberculosis.
Isoniazid treatment resulted in encephalopathy, which resolved after stopping the drug and increasing pyridoxine.
Elevated adenosine deaminase levels supported the diagnosis of peritoneal TB, despite prior negative AFB stains.

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Case report highlights the challenges in diagnosing tuberculosis and its rare toxic effects on the brain.

Scherr et al. (2026) studied this question.

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