Cross-sectional study examines hypertension and cardiac changes related to cyst burden in children with ADPKD, indicating significant cardiovascular risks.
Key Points
The study aims to evaluate hypertension prevalence in children with autosomal dominant polycystic kidney disease and its association with lipid structure and function.
Single-centre, cross-sectional study involving children under 18 years with ADPKD.
Data collected included demographics, blood pressure measurements, biochemistry, and echocardiography, with cyst burden assessed via kidney ultrasound.
Participants were categorized based on blood pressure into 'High BP' and normotensive groups.
Hypertension prevalence was found to be 12% among 116 children, with masked hypertension noted in 8 of them.
Children with High BP had higher cyst burden (56% vs. 34%, P = 0.036) and left ventricular hypertrophy (16.6% vs. 4.6%, P = 0.034).
Cyst burden was identified as an independent predictor of indexed left ventricular mass.