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May 20, 2026American Journal of Respiratory and Critical Care Medicine

A106-17 Association Between Genetic Ancestry and Urinary Metabolites of Extremely Premature Infants at High Risk of Developing Bronchopulmonary Dysplasia

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Authors

TMT I Malave-MendezUniversity of California, San FranciscoMGM A GuardadoUniversity of California, San FranciscoCCC ChapinUniversity of California, San Francisco

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Implication

Randomized trial identifies urinary metabolites linked to genetic ancestry in premature infants, suggesting ancestry affects disease risk.

Key Points

  • Identify urinary metabolites associated with genetic ancestry in premature infants at high risk for bronchopulmonary dysplasia.
  • Performed untargeted metabolomics on 342 urine samples from 171 premature infants from the TOLSURF cohort.
  • Analyzed metabolites at two timepoints between days 5-15 and 23-32 postnatal age using linear regression, adjusting for various factors.
  • Stratified analyses by maternal race/ethnicity to evaluate associations with genomic ancestry.
  • 980 metabolites across 92 metabolic sub-pathways identified; 92 metabolites associated with African ancestry at timepoint 1 (p < 0.05).
  • At timepoint 2, 30 metabolites associated with African, 19 with Amerindigenous, and 12 with European ancestry (p < 0.05).
  • 13 metabolites consistently associated with the same ancestry at both timepoints, linked to pathways relevant in bronchopulmonary dysplasia.

Cite This Study

Malave-Mendez et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5114f03e14405aa9d587https://doi.org/10.1093/ajrccm/aamag162.1134
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolomic Analysis Reveals the Association of Severe Bronchopulmonary Dysplasia with Gut Microbiota and Oxidative Response in Extremely Preterm Infants2024 · 3 citations
  2. 2Early prediction of bronchopulmonary dysplasia by urinary metabolomics: a case–control study2025 · 4 citations
  3. 3Urine Metabolomics to Predict Bronchopulmonary Dysplasia: A Single‐Center Prospective Study2026 · 1 citations
  4. 4Targeted blood metabolomics in infants with bronchopulmonary dysplasia2024
  5. 5High-resolution metabolomics of maternal polybrominated diphenyl ethers (PBDE) exposure and preterm birth in the Atlanta African American Maternal-Child Cohort2026