This study provides an accurate assessment of radiotherapy-induced tissue changes in prostate cancer when relying solely on serum prostate-specific antigen kinetics. The current study aims to explore the role of quantitative magnetic resonance imaging and radiomic analyses. In this exploratory prospective study, 22 patients with histologically confirmed prostate cancer underwent multiparametric magnetic resonance imaging at three time points: pre-treatment, mid-treatment, and two months post-radiotherapy. Quantitative imaging analysis included total prostate volume, T2, apparent diffusion coefficient—ADC, and T2* mapping, alongside T2-weighted and diffusion-weighted radiomic feature extraction. Longitudinal changes and dose correlations were analyzed using repeated-measures ANOVA and linear mixed-effects models. Prostate volume increased from 44.22 ± 21.26 cm3 at baseline to 51.11 ± 22.36 cm3 mid-treatment (p 0.05). Radiomic features, particularly from DWI, exhibited subtle time- and dose-dependent variations. Radiation dose was significantly associated with volume and T2, but not with ADC or T2*. These findings suggest that quantitative MRI biomarkers combined with radiomic analysis may provide objective, non-invasive measures of early prostate cancer radiotherapy-induced changes. These imaging-derived metrics may capture early treatment-related tissue alterations and could provide exploratory signals for early treatment evaluation in prostate cancer, although their relationship with biochemical markers requires further validation.
Bekou et al. (Sun,) studied this question.